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Literature summary extracted from

  • Winder, W.W.; Hardie, D.G.
    AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes (1999), Am. J. Physiol., 277, E1-10.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.31 medicine defects or disuse of the AMPK signaling system would be predicted to result in many of the metabolic perturbations observed in type 2 diabetes mellitus Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 liver
-
 Homo sapiens
-
2.7.11.31 pancreas
-
 Homo sapiens
-
2.7.11.31 skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 ATP + acetyl-CoA carboxylase
-
 Homo sapiens ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.31 ATP + adipose hormone-sensitive lipase
-
 Homo sapiens ADP + adipose hormone-sensitive lipase phosphate
-
 ?
2.7.11.31 additional information phosphorylates key target proteins that control flux through metabolic pathways of hepatic ketogenesis, cholesterol synthesis, adipocyte lipolysis and skeletal muscle fatty acid oxidation Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.31 heterotrimer
-
 Homo sapiens