Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A497V | significantly increased activity | Homo sapiens |
A513_R514insP | insertion, severe degradation of the subunit | Homo sapiens |
D178H | increased alpha/beta subunit ratio, very low activity | Homo sapiens |
DELTA408 | catalytically inactive | Homo sapiens |
DELTA499 | severe degradation of the subunit | Homo sapiens |
DELTA514 | severe degradation of the subunit | Homo sapiens |
E168K | increased alpha/beta subunit ratio, very low activity | Homo sapiens |
G131R | catalytically inactive | Homo sapiens |
G198D | catalytically inactive | Homo sapiens |
L519P | complete degradation of the subunit | Homo sapiens |
M442T | catalytically inactive | Homo sapiens |
N536D | complete degradation of the subunit | Homo sapiens |
P228L | increased alpha/beta subunit ratio, very low activity | Homo sapiens |
R165W | increased alpha/beta subunit ratio, very low activity | Homo sapiens |
R410W | very low activity | Homo sapiens |
R44P | catalytically inactive | Homo sapiens |
R512C | severe degradation of the subunit | Homo sapiens |
S106R | catalytically inactive | Homo sapiens |
V205D | catalytically inactive | Homo sapiens |
V205D | increased alpha/beta subunit ratio | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required to form a complex with ATP | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
800000 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + propanoyl-CoA + HCO3- | Homo sapiens | key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
cDNA encoding for the alpha subunit | - |
Homo sapiens | P05166 | cDNA encoding for the beta subunit | - |
Purification (Comment) | Organism |
---|---|
recombinant enzymes from Escherichia coli | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + propanoyl-CoA + HCO3- | - |
Homo sapiens | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? | |
ATP + propanoyl-CoA + HCO3- | key enzyme in catabolic pathways for odd-chain fatty acids, cholesterol and branched chain amino acids | Homo sapiens | ADP + phosphate + (S)-methylmalonyl-CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
dodecamer | 6 alpha and 6 beta subunits | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
biotin | bound to enzyme | Homo sapiens |