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Literature summary for 6.4.1.1 extracted from

  • Kukavica-Ibrulj, I.; Sanschagrin, F.; Peterson, A.; Whiteley, M.; Boyle, B.; Mackay, J.; Levesque, R.C.
    Functional genomics of PycR, a LysR family transcriptional regulator essential for maintenance of Pseudomonas aeruginosa in the rat lung (2008), Microbiology, 154, 2106-2118.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
genes pycA and pycB encoding two subunits are divergently transcribed upstream of pycR encoding for a pyruvate carboxylase regulator PycR, genomic organization of the PA5436-5435, pycAB, operon and the PA5437 or pycR gene, overview Pseudomonas aeruginosa

Protein Variants

Protein Variants Comment Organism
additional information mutant strain STM5437contains an insertion in the PA5437 or pycR gene encoding for a pyruvate carboxylase regulator, PycR inactivation results in 100000fold attenuation of virulence in the rat lung in vivo, phenotype, overview Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa the enzyme is regulated by a pyruvate carboxylase regulator, encoded by gene PA5437 or pycR, PycR inactivation results in 100 000fold attenuation of virulence in the rat lung in vivo, PycR is a regulator with pleiotropic effects on virulence factors, such as lipase and esterase expression and biofilm formation, which are important for maintenance of Pseudomonas aeruginosa in chronic lung infection, overview ?
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Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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 wild-type strain PAO1, genes pycA and pycB ecoding pyruvate carboxylase subunits PycA and PycB
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is regulated by a pyruvate carboxylase regulator, encoded by gene PA5437 or pycR, PycR inactivation results in 100 000fold attenuation of virulence in the rat lung in vivo, PycR is a regulator with pleiotropic effects on virulence factors, such as lipase and esterase expression and biofilm formation, which are important for maintenance of Pseudomonas aeruginosa in chronic lung infection, overview Pseudomonas aeruginosa ?
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Subunits

Subunits Comment Organism
oligomer two pyruvate carboxylase subunits PycA and PycB Pseudomonas aeruginosa