Cloned (Comment) | Organism |
---|---|
stable overexpression in enzyme-deficient INS-1 insulinoma cell line | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | stable overexpression of the enzyme in INS-1 cells leads to significantly upregulated insulin secretion and cell proliferation, while enzyme downregulation by siRNA expression reduces insulin secretion and cell proliferation, phenotypes, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phenylacetic acid | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate + HCO3- | Rattus norvegicus | the enzyme is involved in mitochondrial metabolism | ADP + phosphate + oxaloacetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic beta cell | enzyme activity is preserved in the islets of obese animals, but it is reduced in the islets of animal models of type 2 diabetes | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate + HCO3- | - |
Rattus norvegicus | ADP + phosphate + oxaloacetate | - |
? | |
ATP + pyruvate + HCO3- | the enzyme is involved in mitochondrial metabolism | Rattus norvegicus | ADP + phosphate + oxaloacetate | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |