Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.4.1.1 extracted from

  • Mukhopadhyay, B.; Stoddard, S.F.; Wolfe, R.S.
    Purification, regulation, and molecular and biochemical characterization of pyruvate carboxylase from Methanobacterium thermoautotrophicum (1998), J. Biol. Chem., 273, 5155-5166.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
acetyl-CoA not required Methanothermobacter thermautotrophicus

Cloned(Commentary)

Cloned (Comment) Organism
-
Methanothermobacter thermautotrophicus

General Stability

General Stability Organism
Mg2+ stabilizes Methanothermobacter thermautotrophicus

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate
-
Methanothermobacter thermautotrophicus
ADP weak Methanothermobacter thermautotrophicus
ATP at high concentrations Methanothermobacter thermautotrophicus
Co2+ in presence of Mg2+ Methanothermobacter thermautotrophicus
ITP weak Methanothermobacter thermautotrophicus
L-Asp no inhibition Methanothermobacter thermautotrophicus
Mn2+ presence of Mg2+ Methanothermobacter thermautotrophicus
Zn2+ in presence of Mg2+ Methanothermobacter thermautotrophicus

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ divalent metal required, Mg2+, Mn2+ or Co2+ Methanothermobacter thermautotrophicus
Mg2+ divalent metal required, Mg2+, and with lower efficiency Mn2+ or Co2+ Methanothermobacter thermautotrophicus
Mn2+ divalent metal required, Mg2+, Mn2+ or Co2+ Methanothermobacter thermautotrophicus

Organism

Organism UniProt Comment Textmining
Methanothermobacter thermautotrophicus
-
-
-
Methanothermobacter thermautotrophicus DELTAH
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Methanothermobacter thermautotrophicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate + HCO3-
-
Methanothermobacter thermautotrophicus ADP + phosphate + oxaloacetate
-
?
ATP + pyruvate + HCO3-
-
Methanothermobacter thermautotrophicus DELTAH ADP + phosphate + oxaloacetate
-
?