Protein Variants | Comment | Organism |
---|---|---|
additional information | downregulation of CAD, i.e. carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, by specific siRNA | Hepacivirus C |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
leflunomide | - |
Hepacivirus C | |
additional information | both the Luc-1b replicon and JFH1-2a virus expression inhibit CAD | Hepacivirus C |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Hepacivirus C | the enzyme is organized as CAD, i.e. carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, a tripartite enzyme that catalyzes the first three steps of pyrimidine biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
HCV, gene CAD | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is organized as CAD, i.e. carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, a tripartite enzyme that catalyzes the first three steps of pyrimidine biosynthesis | Hepacivirus C | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carbamoyl-phosphate synthetase 2 | - |
Hepacivirus C |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Hepacivirus C |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is organized as CAD, i.e. carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, a tripartite enzyme that catalyzes the first three steps of pyrimidine biosynthesis | Hepacivirus C |
physiological function | the enzyme is essential for HCV infection and replication in human liver cells | Hepacivirus C |