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Literature summary for 6.3.5.5 extracted from

  • Arioli, S.; Monnet, C.; Guglielmetti, S.; Mora, D.
    Carbamoylphosphate synthetase activity is essential for the optimal growth of Streptococcus thermophilus in milk (2009), J. Appl. Microbiol., 107, 348-354.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene carB, DNA and amino acid sequence determination and analysis Streptococcus thermophilus

Protein Variants

Protein Variants Comment Organism
additional information construction by gene replacement and phenotype of a carbamoylphosphate synthetase-negative mutant A17, i.e. DELTAcarB, overview. CO2 depletion or carB gene inactivation determines the auxotrophy of Streptococcus thermophilus for L-arginine and uracil. The parent strain grows faster than the mutant, even when milk is supplemented with uracil or arginine Streptococcus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + L-glutamine + HCO3- + H2O Streptococcus thermophilus
-
2 ADP + phosphate + L-glutamate + carbamoyl phosphate
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus thermophilus B2G3Q3 carB; DSM20617, gene carB
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture growth medium is bovine milk Streptococcus thermophilus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-glutamine + HCO3- + H2O
-
Streptococcus thermophilus 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
-
?

Synonyms

Synonyms Comment Organism
CPS
-
Streptococcus thermophilus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Streptococcus thermophilus

General Information

General Information Comment Organism
physiological function carbamoylphosphate synthetase activity is essential for the optimal growth and acidification of Streptococcus thermophilus in cow milk Streptococcus thermophilus