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Literature summary for 6.3.5.5 extracted from

  • Thoden, J.B.; Raushel, F.M.; Wesenberg, G.; Holden, H.M.
    The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase (1999), J. Biol. Chem., 274, 22502-22507.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
L-ornithine
-
 Escherichia coli
potassium
-
 Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
in presence of both IMP and ornithine, structural analysis of the nucleotide monophosphate allosteric binding site for enzyme Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information IMP binds to enzyme but the actual effect of this ligand is dependent upon temperature and assay conditions Escherichia coli
UMP
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + L-Gln + HCO3- + H+ + H2O Escherichia coli the product carbamoyl phosphate is utilized in the pyrimidine and arginine biosynthetic pathways 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
-
 Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
2 ATP + L-Gln + HCO3- + H+ + H2O the product carbamoyl phosphate is utilized in the pyrimidine and arginine biosynthetic pathways Escherichia coli 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
-
 ?
2 ATP + NH4+ + HCO3-
-
 Escherichia coli 2 ADP + phosphate + carbamoyl phosphate
-
 ?

Subunits

Subunits Comment Organism
heterodimer alpha,beta, that readly coverts to an tetrameric species: 4 * alpha, beta in presence of positive allosteric effectors Escherichia coli