Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.5.5 extracted from

  • Thoden, J.B.; Wesenberg, G.; Raushel, F.M.; Holden, H.M.
    Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding (1999), Biochemistry, 38, 2347-2357.
    View publication on PubMed
Search for more literature for 6.3.5.5

Activating Compound

Activating Compound Comment Organism Structure
ornithine
-
 Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
the structure of enzyme cocrystallized in the presence of the 5’-adenylylimidodiphosphate, is determined to 2.1 A by X-ray crystallographic analysis, the three active sites of enzyme communicate via domain movements, the first example of such a domain movement is described Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
UMP
-
 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
 alpha,beta, 1 * 42000 + 1 * 118000 Escherichia coli
118000
-
 alpha,beta, 1 * 42000 + 1 * 118000 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + L-Gln + HCO3- Escherichia coli the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
-
 Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
2 ATP + L-Gln + HCO3- the product carbamoyl phosphate is an essential precursor of arginine and pyrimidine biosynthesis Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
2 ATP + NH4+ + HCO3-
-
 Escherichia coli 2 ADP + phosphate + carbamoyl phosphate
-
 ?

Subunits

Subunits Comment Organism
heterodimer alpha,beta, 1 * 42000 + 1 * 118000 Escherichia coli