Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ala | inhibits glutamine hydrolysis and Gln-dependent carbamoyl phosphate synthesis | Rattus norvegicus | |
Gly | 10 mM, inhibition of glutaminase activity | Rattus norvegicus | |
L-Glu | inhibits glutaminase activity moderately | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | MgATP2- or Mg2+ enhances glutaminase activity | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Gln + HCO3- | Rattus norvegicus | catalyzes the first step of de novo pyrimidine biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatoma ascites cell | AH13 | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + L-Gln + HCO3- | - |
Rattus norvegicus | 2 ADP + phosphate + L-Glu + carbamoyl phosphate | - |
? | |
ATP + L-Gln + HCO3- | catalyzes the first step of de novo pyrimidine biosynthesis | Rattus norvegicus | ? | - |
? | |
additional information | hydrolysis of L-Gln in absence of the other substrates, at 5.9% the rate of glutamine hydrolysis in the complete system | Rattus norvegicus | ? | - |
? |