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Literature summary for 6.3.5.4 extracted from
- The N-terminal cysteine of human asparagine synthetase is essential for glutamine-dependent activity (1989), J. Biol. Chem., 264, 19475-19477.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| mutant enzyme in which the N-terminal Cys is replaced by Ala is expressed in Saccharomyces | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | the replacement of the N-terminal Cys by Ala results in the loss of the Gln-dependent Asn synthetase activity, while the NH4+-dependent activity remains unaffected | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Asp + L-Gln | - |
Homo sapiens | AMP + diphosphate + Asn + Glu | - |
? |  |
| ATP + L-Asp + NH3 | - |
Homo sapiens | AMP + diphosphate + Asn | - |
? | |
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Release 2023.1 (January 2023)
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