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Literature summary for 6.3.5.2 extracted from

  • Jewett, M.W.; Lawrence, K.A.; Bestor, A.; Byram, R.; Gherardini, F.; Rosa, P.A.
    GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle (2009), J. Bacteriol., 191, 6231-6241.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene guaA, the guaAB operon of Borrelia burgdorferi is present on plasmid cp26 Borreliella burgdorferi

Organism

Organism UniProt Comment Textmining
Borreliella burgdorferi
-
gene guaA
-

Synonyms

Synonyms Comment Organism
GuaA
-
Borreliella burgdorferi

General Information

General Information Comment Organism
metabolism key enzyme in the purine salvage pathways Borreliella burgdorferi
physiological function the enzymatic activities encoded by the guaAB operon are essential for Borrelia burgdorferi mouse infectivity and provide a growth advantage to spirochetes in the tick, GuaA protein is expressed during infection of mammalian hosts and is critical for the survival of Borrelia burgdorferi in the infection cycle, overview Borreliella burgdorferi