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Literature summary for 6.3.5.2 extracted from

  • Jiang, L.; Zhao, J.; Guo, R.; Li, J.; Yu, L.; Xu, D.
    Functional characterization and virulence study of ADE8 and GUA1 genes involved in the de novo purine biosynthesis in Candida albicans (2010), FEMS Yeast Res., 10, 199-208.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construction of disruption mutants, the heterozygote GUA1/gua1 strain is hypersensitive to 6-azauracil, a known inhibitor of the IMP dehydrogenase involved in GMP biosynthesis. In a murine model of systemic candidiasis, the virulence of the heterozygous strain is marginally attenuated, while the homozygous mutant gua1/gua1 strain is completely avirulent Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans
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strain CAI4, gene GUA1
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Candida albicans CAI-4
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strain CAI4, gene GUA1
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