Application | Comment | Organism |
---|---|---|
synthesis | importance of guanine synthesis in immune cell function, GMP synthetase is a potential target for immunosuppressive therapy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-Amino-9-D-psicofuranosylpurine | - |
Homo sapiens | |
Decoyinine | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0356 | - |
XMP | native enzyme | Homo sapiens | |
0.043 | - |
XMP | recombinant enzyme | Homo sapiens | |
0.131 | - |
ATP | native enzyme | Homo sapiens | |
0.161 | - |
ATP | recombinant enzyme | Homo sapiens | |
0.405 | - |
Gln | native enzyme | Homo sapiens | |
0.44 | - |
Gln | recombinant enzyme | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
77360 | - |
1 * 77360, density gradient centrifugation and subsequent electrospray MS analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
3.74 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + XMP + NH4+ | - |
Homo sapiens | AMP + diphosphate + GMP | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 77360, density gradient centrifugation and subsequent electrospray MS analysis | Homo sapiens |