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Literature summary for 6.3.5.2 extracted from

  • Spector, T.
    GMP synthetase from Ehrlich ascites cells (1978), Methods Enzymol., 51, 219-224.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
DTT stimulates Mus musculus

General Stability

General Stability Organism
thawing and refreezing does not diminish activity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1,N6-Ethenoadenosine 5'-triphosphate
-
Mus musculus
2-mercaptoethanol
-
Mus musculus
6-thioXMP
-
Mus musculus
adenine 9-beta-D-arabinofuranoside 5'-triphosphate
-
Mus musculus
CTP
-
Mus musculus
diphosphate
-
Mus musculus
p-chloromercuribenzoate
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0036
-
XMP
-
Mus musculus
0.28
-
ATP
-
Mus musculus
0.68
-
Gln
-
Mus musculus
36
-
NH4+
-
Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
gel filtration Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
Ehrlich ascites carcinoma cell
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0428
-
-
Mus musculus

Storage Stability

Storage Stability Organism
-70°C, stable for at least 1 year Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine 5-phosphate
-
Mus musculus AMP + phosphate + 1-ribosyl-4-hydroxy-6-aminopyrazolo[3,4-d]pyrimidine 5'-phosphate
-
?
ATP + 6-thioXMP + NH4+
-
Mus musculus AMP + phosphate + 6-thioGMP
-
?
ATP + 8-azaXMP + NH4+
-
Mus musculus AMP + phosphate + 8-azaGMP
-
?
ATP + beta-arabinofuranosyl-XMP
-
Mus musculus AMP + phosphate + beta-arabinofuranosylGMP
-
?
ATP + dXMP + NH4+ at 4.3% of the activity relative to XMP Mus musculus AMP + phosphate + dGMP
-
?
ATP + XMP + Gln higher Km value for NH4+ compared with Gln Mus musculus AMP + diphosphate + GMP + Glu
-
?
ATP + XMP + NH4+ higher Km value for NH4+ compared with Gln Mus musculus AMP + diphosphate + GMP
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
-
Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
7.4 8.6 more than 80% of maximal activity at pH 7.4 and 8.6 Mus musculus