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Literature summary for 6.3.4.4 extracted from

  • Pimkin, M.; Markham, G.D.
    The CBS subdomain of inosine 5-monophosphate dehydrogenase regulates purine nucleotide turnover (2008), Mol. Microbiol., 68, 342-359.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information the activity of AMPsS in crude dialyzed cell extracts is 2times lower in the guaBDELTACBS mutant compared with the wild type strain Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information GMP is not a strong inhibitor of AMPsS at physiological concentrations Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
strains BW25113 and MP101
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00207
-
enzyme from guaBDELTACBS mutant crude extract Escherichia coli
0.00493
-
enzyme from wild type crude extract Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + IMP + L-Asp
-
Escherichia coli GDP + phosphate + adenylosuccinate
-
?

Synonyms

Synonyms Comment Organism
Adenylosuccinate synthetase
-
Escherichia coli
AMPsS
-
Escherichia coli