Any feedback?
Literature summary for 6.3.2.4 extracted from
- Inhibition of D-alanyl-D-alanine ligase in different bacterial species by amino phosphonic acids (1979), Curr. Microbiol., 2, 113-117.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-aminoethylphosphonate | weak | Pseudomonas aeruginosa |  |
| D-(1-Aminoethyl)phosphonic acid | DL- | Pseudomonas aeruginosa | |
| D-cycloserine | - |
Pseudomonas aeruginosa | |
| D-cycloserine | - |
Staphylococcus aureus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Staphylococcus aureus | |
| additional information | - |
additional information | - |
Pseudomonas aeruginosa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Ala + Ala | Staphylococcus aureus | one step in peptidoglycan synthesis: the formation of D-Ala-D-Ala, the terminal dipeptide of the UDP-N-acetylmuramylpentapeptide | ? | - |
? | |
| ATP + Ala + Ala | Pseudomonas aeruginosa | one step in peptidoglycan synthesis: the formation of D-Ala-D-Ala, the terminal dipeptide of the UDP-N-acetylmuramylpentapeptide | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Ala + Ala | one step in peptidoglycan synthesis: the formation of D-Ala-D-Ala, the terminal dipeptide of the UDP-N-acetylmuramylpentapeptide | Staphylococcus aureus | ? | - |
? | |
| ATP + Ala + Ala | one step in peptidoglycan synthesis: the formation of D-Ala-D-Ala, the terminal dipeptide of the UDP-N-acetylmuramylpentapeptide | Pseudomonas aeruginosa | ? | - |
? | |
| ATP + D-Ala + D-Ala | - |
Staphylococcus aureus | ADP + phosphate + D-Ala-D-Ala | - |
? | |
| ATP + D-Ala + D-Ala | - |
Pseudomonas aeruginosa | ADP + phosphate + D-Ala-D-Ala | - |
? | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
