Literature summary for 6.3.2.2 extracted from

de Tudela, M.V.; Delgado-Esteban, M.; Cuende, J.; Bolanos, J.P.; Almeida, A.
Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase (2010), J. Neurochem., 113, 819-825.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
IMR-32 cell	oncogene MYCN-amplified cells	Homo sapiens	-
SH-SY5Y cell	oncogene MYCN-non-amplified cells	Homo sapiens	-
SK-N-BE(2) cell	oncogene MYCN-amplified cells	Homo sapiens	-
SK-N-SH cell	oncogene MYCN-non-amplified cells	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	oncogen MYCN directly binds to an E-box containing GCL catalytic subunit promoter and over-expression of MYCN in MYCN-non-amplified cells stimulates GCL catalytic subunit expression and provides resistance to oxidative damage. Knock-down of MYCN in MYCN-amplified cells decreases GCL catalytic subunit expression and sensitizes them to oxidative damage	up

General Information

General Information	Comment	Organism
physiological function	the high resistance of MYCN-amplified neuroblastoma cells against oxidative damage can be accounted for by their greater expression of both the mRNA and protein of the catalytic subunit of glutamate-cysteine ligase, the rate-limiting step in GSH biosynthesis. MYCN directly binds to an E-box containing GCL catalytic subunit promoter and over-expression of MYCN in MYCN-non-amplified cells stimulates GCL catalytic subunit expression and provides resistance to oxidative damage. Knock-down of MYCN in MYCN-amplified cells decreases GCL catalytic subunit expression and sensitizes them to oxidative damage. GCL catalytic subunit knock-down enhances the vulnerability of MYCN-amplified cells to oxidative damage	Homo sapiens

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Release 2023.1 (January 2023)