Any feedback?
Literature summary for 6.3.2.2 extracted from
- Hypoxia and kinase activity regulate lung epithelial cell glutathione (2010), Exp. Lung Res., 36, 45-56.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | decrease of enzyme activity in hypoxia: 20% after 6 h, 17% after 12 h, 23% after 24 h, hypoxia-induced decrease in enzyme activity may be prevented by MAPK inhibition and catalase | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutamate + ATP + L-cysteine | assay at pH 8.2 | Homo sapiens | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GCL | - |
Homo sapiens |
| glutamate cysteine ligase | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.2 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
