Application | Comment | Organism |
---|---|---|
pharmacology | co-treatment by indomethacin and doxorubicin increases the cytotoxicitiy of doxorubicin by decreasing the intracellular contents of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase. Indomethacin inhibits the gamma-glutamylcysteine synthetase promoter activity. | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
activity of the gamma-glutamylcysteine synthetase promoter decreases after indomethacin treatment | - |
Homo sapiens | - |
leukemia cell. Cells show increased expression of gamma-glutamylcysteine synthetase. Expression decreases by indomethacin treatment | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | indomethacin inhibits the gamma-glutamylcysteine synthetase promoter activity. Co-treatment by indomethacin and doxorubicin increases the cytotoxicitiy of doxorubicin by decreasing the intracellular contents of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase | down |