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Literature summary for 6.3.2.2 extracted from

  • Liu, X.P.; Goldring, C.E.; Wang, H.Y.; Copple, I.M.; Kitteringham, N.R.; Park, B.K.; Wei, W.
    Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC) (2008), Phytother. Res., 22, 367-371.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information extracts of Ginkgo biloba induces GCL catalytic subunit, GCLC, in HepG2 and Hep1c1c7 cell lines Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + L-cysteine Homo sapiens GCL is the rate-limiting enzyme in glutathione biosynthesis, its catalytic subunit GCLC determines this de novo synthesis. Induction of GCLC is a strategy to enhance the antioxidant capability in cells ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + L-cysteine
-
Homo sapiens ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
?
ATP + L-glutamate + L-cysteine GCL is the rate-limiting enzyme in glutathione biosynthesis, its catalytic subunit GCLC determines this de novo synthesis. Induction of GCLC is a strategy to enhance the antioxidant capability in cells Homo sapiens ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
?

Synonyms

Synonyms Comment Organism
glutamate cysteine ligase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens