Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | resveratrol and 4-hydroxy-2-nonenal both increases GSH and the mRNA contents of both the catalytic GCLC and modulatory GCLM subunit of GCL, both agents show synergictic effects when applied together, overview. The cis-element Nrf2/EpRE signalling is involved in resveratrol-mediated induction of GCL genes | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | Homo sapiens | - |
ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | Homo sapiens | the cis-element signaling of Nrf2/EpRE is involved in resveratrol-mediated induction of GCL genes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
genes gclC and gclM encoding the two subunits of the enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchus | bronchial epithelial cells | Homo sapiens | - |
epithelium | bronchial epithelial cells | Homo sapiens | - |
HBE-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | - |
Homo sapiens | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | the cis-element signaling of Nrf2/EpRE is involved in resveratrol-mediated induction of GCL genes | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCL | - |
Homo sapiens |
glutamate cysteine ligase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |