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Literature summary for 6.3.2.17 extracted from

  • Jiang, L.; Liu, Y.; Sun, H.; Han, Y.; Li, J.; Li, C.; Guo, W.; Meng, H.; Li, S.; Fan, Y.; Zhang, C.
    The mitochondrial folylpolyglutamate synthetase gene is required for nitrogen utilization during early seedling development in Aarabidopsis (2013), Plant Physiol., 161, 971-989.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.17

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Arabidopsis thaliana 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate Arabidopsis thaliana
-
 ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana F4J2K2 DFC; gene dfc encoding isozyme DFC
-
Arabidopsis thaliana F4K2A1 FPGS1; gene dfb encoding isozyme FPGS1
-

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
-
 Arabidopsis thaliana ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
-
 ?

Synonyms

Synonyms Comment Organism
Folylpolyglutamate synthetase
-
 Arabidopsis thaliana
FPGS1 gene name, UniProt Arabidopsis thaliana
FPGS2 gene name, UniProt Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction deficiency in N utilization in an Arabidopsis thaliana transfer DNA insertion mutant of the mitochondrial folylpolyglutamate synthetase gene DFC. The mutant seedlings display several metabolic changes that are typical of plant responses to low-N stress, including increased levels of starch and anthocyanin synthesis as well as decreased levels of soluble protein and free amino acid, as compared to wild-type seedlings with sufficient external N. Isozyme FPGS1 can partially compensate for isozyme DFC defect. No significant differences in growth, development, or fertility are observed between wild-type and dfc plants in soil Arabidopsis thaliana
malfunction isozyme FPGS1 can partially compensate for isozyme DFC defect Arabidopsis thaliana
additional information folate profiles in Arabidopsis seedlings, overview Arabidopsis thaliana
physiological function the mitochondrial folylpolyglutamate synthetase catalyzes the conjugation of glutamate residues to the tetrahydrofolate during folate synthesis Arabidopsis thaliana