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Literature summary for 6.3.2.17 extracted from

  • Leclerc, G.J.; York, T.A.; Hsieh-Kinser, T.; Barredo, J.C.
    Molecular basis for decreased folylpoly-gamma-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell line (2007), Leuk. Res., 31, 293-299.
    View publication on PubMed
Search for more literature for 6.3.2.17

Cloned(Commentary)

Cloned (Comment) Organism
expressed in AuxB1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
A382T 94% of the wild type enzyme activity Homo sapiens
C209R 8% of the wild type enzyme activity Homo sapiens
G569C 13% of the wild type enzyme activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CCRF-CEM cell
-
 Homo sapiens
-
leukemia cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + methotrexate + Glu
-
 Homo sapiens ADP + phosphate + methotrexyl-Glu
-
 ?

Synonyms

Synonyms Comment Organism
Folylpoly-gamma-glutamate synthetase
-
 Homo sapiens
FPGS
-
 Homo sapiens