Literature summary for 6.3.2.17 extracted from

Sohn, K.J.; Smirnakis, F.; Moskovitz, D.N.; Novakovic, P.; Yates, Z.; Lucock, M.; Croxford, R.; Kim, Y.I.
Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate (2004), Gut, 53, 1825-1831.

Cloned(Commentary)

Cloned (Comment)	Organism
HCT-116 cells stable transfected with the sense or antisense FPGS cDNA. Compared with cells expressing endogenous FPGS, those overexpressing FPGS have significantly faster growth rates and higher concentrations of total folate and long-chain folate polyglutamates while antisense FPGS inhibition produces opposite results. FPGS overexpression significantly enhances, whereas FPGS inhibition decreases chemosensitivity to 5-fluorouracil. No significant difference in chemosensitivity to methotrexate is observed	Homo sapiens

Cloned (Comment)

Organism

HCT-116 cells stable transfected with the sense or antisense FPGS cDNA. Compared with cells expressing endogenous FPGS, those overexpressing FPGS have significantly faster growth rates and higher concentrations of total folate and long-chain folate polyglutamates while antisense FPGS inhibition produces opposite results. FPGS overexpression significantly enhances, whereas FPGS inhibition decreases chemosensitivity to 5-fluorouracil. No significant difference in chemosensitivity to methotrexate is observed

Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
5-fluorouracil	FPGS overexpression significantly enhances chemosensitivity to 5-fluorouracil, FPGS inhibition decreases chemosensitivity to 5-fluorouracil	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
folyl-gamma-glutamate synthetase	-	Homo sapiens
FPGS	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)