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Literature summary for 6.3.2.17 extracted from

  • Shane, B.; Garrow, T.; Brenner, A.; Chen, L.; Choi, Y.J.; Hsu, J.C.; Stover, P.
    Folylpoly-gamma-glutamate synthetase (1993), Chem. Biol. Pteridines Folates (J. E. Ayling et al eds. ) Plenum Press New York, , 629-634.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Homo sapiens
overexpression in Escherichia coli Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
eukaryota 5829
-
cytosol
-
Homo sapiens 5829
-
mitochondrion
-
eukaryota 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+ maximal activity at 20 mM Homo sapiens
K+ maximal activity at 20 mM Sus scrofa
K+ maximal activity at 20 mM Saccharomyces cerevisiae
K+ required form maximal activity Escherichia coli
K+ required form maximal activity Homo sapiens
K+ required form maximal activity Sus scrofa
K+ required form maximal activity Saccharomyces cerevisiae
K+ required form maximal activity Corynebacterium sp.
K+ required form maximal activity Lacticaseibacillus casei
K+ maximal activity at 200 mM Escherichia coli
K+ maximal activity at 200 mM Sus scrofa
K+ maximal activity at 200 mM Corynebacterium sp.
K+ maximal activity at 200 mM Lacticaseibacillus casei
Mg2+ required Escherichia coli
Mg2+ required Homo sapiens
Mg2+ required Sus scrofa
Mg2+ required Saccharomyces cerevisiae
Mg2+ required Corynebacterium sp.
Mg2+ required Lacticaseibacillus casei

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
62000
-
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents ?
-
?
additional information Saccharomyces cerevisiae enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents ?
-
?
additional information eukaryota mitochondrial enzyme is required for mitochondrial one carbon metabolism and for normal one carbon flux in the cytosol ?
-
?

Organism

Organism UniProt Comment Textmining
Corynebacterium sp.
-
-
-
Escherichia coli
-
-
-
eukaryota
-
-
-
Homo sapiens
-
-
-
Lacticaseibacillus casei
-
-
-
Saccharomyces cerevisiae
-
-
-
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme also posseses dihydrofolate synthetase activity Escherichia coli ?
-
?
additional information enzyme also posseses dihydrofolate synthetase activity Corynebacterium sp. ?
-
?
additional information no dihydrofolate synthetase activity Homo sapiens ?
-
?
additional information no dihydrofolate synthetase activity Sus scrofa ?
-
?
additional information no dihydrofolate synthetase activity Saccharomyces cerevisiae ?
-
?
additional information no dihydrofolate synthetase activity Lacticaseibacillus casei ?
-
?
additional information enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents Homo sapiens ?
-
?
additional information enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents Saccharomyces cerevisiae ?
-
?
additional information mitochondrial enzyme is required for mitochondrial one carbon metabolism and for normal one carbon flux in the cytosol eukaryota ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information
-
Escherichia coli
additional information
-
additional information
-
Homo sapiens
additional information
-
additional information
-
Sus scrofa
additional information
-
additional information
-
Corynebacterium sp.
additional information
-
additional information
-
Lacticaseibacillus casei

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.4
-
-
Escherichia coli
9.4
-
-
Homo sapiens
9.4
-
-
Sus scrofa
9.5
-
-
Sus scrofa
9.5
-
-
Saccharomyces cerevisiae
9.5
-
-
Corynebacterium sp.
9.5
-
-
Lacticaseibacillus casei