Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Borate | - |
Corynebacterium sp. | |
phosphate | - |
Corynebacterium sp. | |
phosphate | - |
Lacticaseibacillus casei | |
phosphate | - |
Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | required form maximal activity | Escherichia coli | |
K+ | required form maximal activity | Sus scrofa | |
K+ | required form maximal activity | Corynebacterium sp. | |
K+ | required form maximal activity | Lacticaseibacillus casei | |
K+ | maximal activity at 200 mM | Escherichia coli | |
K+ | maximal activity at 200 mM | Sus scrofa | |
K+ | maximal activity at 200 mM | Corynebacterium sp. | |
K+ | maximal activity at 200 mM | Lacticaseibacillus casei | |
Mg2+ | required | Escherichia coli | |
Mg2+ | required | Sus scrofa | |
Mg2+ | required | Corynebacterium sp. | |
Mg2+ | required | Lacticaseibacillus casei | |
Mg2+ | optimal Mg2+ concentration is dependent on ATP concentration | Corynebacterium sp. |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
51000 | - |
gel filtration | Corynebacterium sp. |
53000 | - |
1 * 53000, SDS-PAGE | Corynebacterium sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corynebacterium sp. | - |
- |
- |
Cricetulus griseus | - |
- |
- |
Enterococcus faecalis | - |
- |
- |
Escherichia coli | - |
- |
- |
Lacticaseibacillus casei | - |
- |
- |
Neurospora crassa | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Corynebacterium sp. |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 | formation of a pteroyl-gamma-glutamyl phosphate intermediate | Corynebacterium sp. | |
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 | ordered ter ter mechanism with MgATP binding first to the enzyme, folate second, and glutamate last | Corynebacterium sp. | |
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 | ordered ter ter mechanism with MgATP binding first to the enzyme, folate second, and glutamate last | Lacticaseibacillus casei |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
ovary | - |
Cricetulus griseus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.57 | - |
- |
Corynebacterium sp. |
Storage Stability | Organism |
---|---|
-20°C or -196°C, 50 mM potassium phosphate buffer, pH 7, 50 mM KCl, 30% DMSO | Corynebacterium sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu | - |
Escherichia coli | ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2 | - |
? | |
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu | - |
Rattus norvegicus | ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2 | - |
? | |
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu | - |
Sus scrofa | ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2 | - |
? | |
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu | - |
Corynebacterium sp. | ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2 | - |
? | |
ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | - |
Rattus norvegicus | ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | - |
Lacticaseibacillus casei | ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | n:1 | Sus scrofa | ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | n:1 | Neurospora crassa | ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | n:1 | Corynebacterium sp. | ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5,6,7,8-tetrahydropteroate + Glu | - |
Corynebacterium sp. | ADP + phosphate + 5,6,7,8-terahydropteroyl-Glu | - |
? | |
ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu | n: 1 | Sus scrofa | ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu | n: 1 | Neurospora crassa | ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu | n: 1 | Corynebacterium sp. | ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu | n: 1 | Lacticaseibacillus casei | ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | - |
Rattus norvegicus | ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2 | - |
? | |
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | - |
Sus scrofa | ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2 | - |
? | |
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | - |
Neurospora crassa | ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2 | - |
? | |
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | - |
Lacticaseibacillus casei | ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2 | - |
? | |
ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | - |
Rattus norvegicus | ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | - |
Lacticaseibacillus casei | ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | n: 1 | Sus scrofa | ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | n: 1 | Neurospora crassa | ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | n: 1 | Corynebacterium sp. | ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
ATP + 7,8-dihydropteroate + Glu | - |
Sus scrofa | ADP + phosphate + 7,8-dihydropteroyl-Glu | - |
? | |
ATP + 7,8-dihydropteroate + Glu | - |
Corynebacterium sp. | ADP + phosphate + 7,8-dihydropteroyl-Glu | - |
? | |
ATP + aminopterin + Glu | - |
Rattus norvegicus | ADP + phosphate + aminopteryl-Glu | - |
? | |
ATP + aminopterin + Glu | - |
Sus scrofa | ADP + phosphate + aminopteryl-Glu | - |
? | |
ATP + aminopterin + Glu | - |
Corynebacterium sp. | ADP + phosphate + aminopteryl-Glu | - |
? | |
ATP + aminopterin + Glu | - |
Lacticaseibacillus casei | ADP + phosphate + aminopteryl-Glu | - |
? | |
additional information | - |
Escherichia coli | ? | - |
? | |
additional information | - |
Neurospora crassa | ? | - |
? | |
additional information | - |
Lacticaseibacillus casei | ? | - |
? | |
additional information | dATP and UTP can act as substrate | Corynebacterium sp. | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Escherichia coli |
monomer | - |
Sus scrofa |
monomer | - |
Lacticaseibacillus casei |
monomer | 1 * 53000, SDS-PAGE | Corynebacterium sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.5 | 10 | - |
Corynebacterium sp. |