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Literature summary for 6.3.2.17 extracted from

  • Cichowicz, D.J.; Foo, S.K.; Shane, B.
    Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells (1981), Mol. Cell. Biochem., 39, 209-228.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Borate
-
Corynebacterium sp.
phosphate
-
Corynebacterium sp.
phosphate
-
Lacticaseibacillus casei
phosphate
-
Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
K+ required form maximal activity Escherichia coli
K+ required form maximal activity Sus scrofa
K+ required form maximal activity Corynebacterium sp.
K+ required form maximal activity Lacticaseibacillus casei
K+ maximal activity at 200 mM Escherichia coli
K+ maximal activity at 200 mM Sus scrofa
K+ maximal activity at 200 mM Corynebacterium sp.
K+ maximal activity at 200 mM Lacticaseibacillus casei
Mg2+ required Escherichia coli
Mg2+ required Sus scrofa
Mg2+ required Corynebacterium sp.
Mg2+ required Lacticaseibacillus casei
Mg2+ optimal Mg2+ concentration is dependent on ATP concentration Corynebacterium sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000
-
gel filtration Corynebacterium sp.
53000
-
1 * 53000, SDS-PAGE Corynebacterium sp.

Organism

Organism UniProt Comment Textmining
Corynebacterium sp.
-
-
-
Cricetulus griseus
-
-
-
Enterococcus faecalis
-
-
-
Escherichia coli
-
-
-
Lacticaseibacillus casei
-
-
-
Neurospora crassa
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Corynebacterium sp.

Reaction

Reaction Comment Organism Reaction ID
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 formation of a pteroyl-gamma-glutamyl phosphate intermediate Corynebacterium sp.
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 ordered ter ter mechanism with MgATP binding first to the enzyme, folate second, and glutamate last Corynebacterium sp.
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 ordered ter ter mechanism with MgATP binding first to the enzyme, folate second, and glutamate last Lacticaseibacillus casei

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-
ovary
-
Cricetulus griseus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.57
-
-
Corynebacterium sp.

Storage Stability

Storage Stability Organism
-20°C or -196°C, 50 mM potassium phosphate buffer, pH 7, 50 mM KCl, 30% DMSO Corynebacterium sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu
-
Escherichia coli ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2
-
?
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu
-
Rattus norvegicus ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2
-
?
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu
-
Sus scrofa ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2
-
?
ATP + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu + Glu
-
Corynebacterium sp. ADP + phosphate + 10-formyl-5,6,7,8-tetrahydropteroyl-Glu2
-
?
ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu
-
Rattus norvegicus ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu
-
Lacticaseibacillus casei ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n:1 Sus scrofa ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n:1 Neurospora crassa ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n:1 Corynebacterium sp. ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5,6,7,8-tetrahydropteroate + Glu
-
Corynebacterium sp. ADP + phosphate + 5,6,7,8-terahydropteroyl-Glu
-
?
ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 1 Sus scrofa ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 1 Neurospora crassa ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 1 Corynebacterium sp. ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu n: 1 Lacticaseibacillus casei ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu
-
Rattus norvegicus ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2
-
?
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu
-
Sus scrofa ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2
-
?
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu
-
Neurospora crassa ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2
-
?
ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu
-
Lacticaseibacillus casei ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2
-
?
ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu
-
Rattus norvegicus ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu
-
Lacticaseibacillus casei ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n: 1 Sus scrofa ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n: 1 Neurospora crassa ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu n: 1 Corynebacterium sp. ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
-
?
ATP + 7,8-dihydropteroate + Glu
-
Sus scrofa ADP + phosphate + 7,8-dihydropteroyl-Glu
-
?
ATP + 7,8-dihydropteroate + Glu
-
Corynebacterium sp. ADP + phosphate + 7,8-dihydropteroyl-Glu
-
?
ATP + aminopterin + Glu
-
Rattus norvegicus ADP + phosphate + aminopteryl-Glu
-
?
ATP + aminopterin + Glu
-
Sus scrofa ADP + phosphate + aminopteryl-Glu
-
?
ATP + aminopterin + Glu
-
Corynebacterium sp. ADP + phosphate + aminopteryl-Glu
-
?
ATP + aminopterin + Glu
-
Lacticaseibacillus casei ADP + phosphate + aminopteryl-Glu
-
?
additional information
-
Escherichia coli ?
-
?
additional information
-
Neurospora crassa ?
-
?
additional information
-
Lacticaseibacillus casei ?
-
?
additional information dATP and UTP can act as substrate Corynebacterium sp. ?
-
?

Subunits

Subunits Comment Organism
monomer
-
Escherichia coli
monomer
-
Sus scrofa
monomer
-
Lacticaseibacillus casei
monomer 1 * 53000, SDS-PAGE Corynebacterium sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5 10
-
Corynebacterium sp.