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Literature summary for 6.3.2.1 extracted from

  • Yang, Y.; Gao, P.; Liu, Y.; Ji, X.; Gan, M.; Guan, Y.; Hao, X.; Li, Z.; Xiao, C.
    A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition (2011), Bioorg. Med. Chem. Lett., 21, 3943-3946.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-(2-{3-[(1E,3E)-hexa-1,3,5-trien-1-yl]phenyl}hydrazinyl)-4-oxobutanoic acid 27% inhibition Mycobacterium tuberculosis
actinomycin D
-
Mycobacterium tuberculosis
methyl 6-amino-4-(benzyloxy)-1H-indole-2-carboxylate 69% inhibition Mycobacterium tuberculosis
nafronyl oxalate
-
Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-pantoate + beta-alanine
-
Mycobacterium tuberculosis AMP + diphosphate + (R)-pantothenate
-
?

Synonyms

Synonyms Comment Organism
PanC
-
Mycobacterium tuberculosis
Pantothenate synthetase
-
Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.02244
-
pH and temperature not specified in the publication Mycobacterium tuberculosis methyl 6-amino-4-(benzyloxy)-1H-indole-2-carboxylate
0.2507
-
pH and temperature not specified in the publication Mycobacterium tuberculosis actinomycin D
0.3984
-
pH and temperature not specified in the publication Mycobacterium tuberculosis nafronyl oxalate