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Literature summary for 6.3.2.1 extracted from

  • White, E.L.; Southworth, K.; Ross, L.; Cooley, S.; Gill, R.B.; Sosa, M.I.; Manouvakhova, A.; Rasmussen, L.; Goulding, C.; Eisenberg, D.; Fletcher, T.M.
    A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase (2007), J. Biomol. Screen., 12, 100-105.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
nafronyl oxalate competitive inhibitor Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.41
-
(R)-pantoate
-
Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-pantoate + beta-alanine
-
Mycobacterium tuberculosis AMP + diphosphate + (R)-pantothenate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.075
-
nafronyl oxalate
-
Mycobacterium tuberculosis