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Literature summary for 6.3.1.2 extracted from

  • Hotter, G.S.; Mouat, P.; Collins, D.M.
    Independent transcription of glutamine synthetase (glnA2) and glutamine synthetase adenylyltransferase (glnE) in Mycobacterium bovis and Mycobacterium tuberculosis (2008), Tuberculosis, 88, 382-389.
    View publication on PubMed
Search for more literature for 6.3.1.2

Application

Application Comment Organism
medicine glutamine synthetase is a target for disruption in the development of vaccines against both bovine and human tuberculosis. Glutamine synthetase is also a potential target for tuberculosis chemotherapy Mycobacterium tuberculosis variant bovis

Cloned(Commentary)

Cloned (Comment) Organism
gene glnA1, genetic organization of glnA1 and glnE, RT-PCR expression analysis, overview Mycobacterium tuberculosis
gene glnA1, genetic organization of glnA1 and glnE, RT-PCR expression analysis, overview Mycobacterium tuberculosis variant bovis
gene glnA2, DNA and amino acid sequence determination and analysis of glnA2, genetic organization of glnA2 and glnE, chromosomal structure of the glnA2/glnE locus, RT-PCR expression analysis, overview Mycobacterium tuberculosis
gene glnA2, DNA and amino acid sequence determination and analysis of glnA2, genetic organization of glnA2 and glnE, chromosomal structure of the glnA2/glnE locus, RT-PCR expression analysis, overview Mycobacterium tuberculosis variant bovis

Protein Variants

Protein Variants Comment Organism
additional information a glnA2 mutant provides protection against infection with virulent Mycobacterium bovis Mycobacterium tuberculosis variant bovis

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mycobacterium tuberculosis
Mg2+
-
 Mycobacterium tuberculosis variant bovis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + NH3 Mycobacterium tuberculosis
-
 ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3 Mycobacterium tuberculosis variant bovis
-
 ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3 Mycobacterium tuberculosis H37Rv
-
 ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3 Mycobacterium tuberculosis variant bovis AF2122/97
-
 ADP + phosphate + L-glutamine
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WN39 gene glnA2
-
Mycobacterium tuberculosis P9WN39 gene glnA1
-
Mycobacterium tuberculosis H37Rv P9WN39 gene glnA2
-
Mycobacterium tuberculosis H37Rv P9WN39 gene glnA1
-
Mycobacterium tuberculosis variant bovis P0A591 gene glnA1
-
Mycobacterium tuberculosis variant bovis P64246 gene glnA
-
Mycobacterium tuberculosis variant bovis AF2122/97 P0A591 gene glnA1
-
Mycobacterium tuberculosis variant bovis AF2122/97 P64246 gene glnA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + NH3
-
 Mycobacterium tuberculosis ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3
-
 Mycobacterium tuberculosis variant bovis ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3
-
 Mycobacterium tuberculosis H37Rv ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3
-
 Mycobacterium tuberculosis variant bovis AF2122/97 ADP + phosphate + L-glutamine
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mycobacterium tuberculosis
ATP
-
 Mycobacterium tuberculosis variant bovis