Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-methionine-sulfoximine | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | Rattus norvegicus | the astrocyte-specific glutamine synthetase plays a key role in glutamate recycling and gamma-aminobutyric acid metabolism, it is involved in nitrosative stress response in the brain, overview | ADP + phosphate + L-glutamine | - |
? | |
additional information | Rattus norvegicus | rats with pentylenetetrazole-induced repetitive epileptic seizures show increased heat shock responseand reduced enzyme activity, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | astrocyte-specific glutamine synthetase | Rattus norvegicus | - |
cerebral cortex | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
additional information | enzyme immunohistochemic analysis, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | - |
Rattus norvegicus | ADP + phosphate + L-glutamine | - |
? | |
ATP + L-glutamate + NH3 | the astrocyte-specific glutamine synthetase plays a key role in glutamate recycling and gamma-aminobutyric acid metabolism, it is involved in nitrosative stress response in the brain, overview | Rattus norvegicus | ADP + phosphate + L-glutamine | - |
? | |
additional information | rats with pentylenetetrazole-induced repetitive epileptic seizures show increased heat shock responseand reduced enzyme activity, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glutamine synthetase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |