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Literature summary for 6.3.1.2 extracted from
- Kinetic characterization and regulation of purified glutamine synthetase from brain of Clarias batrachus (1990), Arch. Int. Physiol. Biochim., 98, 95-101.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | - |
Clarias batrachus |  |
| Asn | - |
Clarias batrachus | |
| Asp | - |
Clarias batrachus | |
| ATP | - |
Clarias batrachus | |
| Carbamoyl phosphate | non-competitive with respect to L-Glu | Clarias batrachus | |
| L-Glu | - |
Clarias batrachus | |
| L-Lys | no inhibition | Clarias batrachus | |
| L-methionine sulfoximine | - |
Clarias batrachus | |
| Leu | - |
Clarias batrachus | |
| UMP | competitive with respect to L-Gln | Clarias batrachus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.833 | - |
ADP | - |
Clarias batrachus | |
| 50 | - |
L-Glu | - |
Clarias batrachus | |
| 62.5 | - |
hydroxylamine | - |
Clarias batrachus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Glu + NH4+ | Clarias batrachus | kinetic regulation of this enzyme may play a significant role in ammonia detoxication and rate of formation of Gln-derived neurotransmitters in fish brain | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clarias batrachus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Clarias batrachus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Clarias batrachus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Glu + NH4+ | - |
Clarias batrachus | ADP + phosphate + L-Gln | - |
? | |
| ATP + L-Glu + NH4+ | kinetic regulation of this enzyme may play a significant role in ammonia detoxication and rate of formation of Gln-derived neurotransmitters in fish brain | Clarias batrachus | ? | - |
? | |
| ATP + L-glutamate + hydroxylamine | - |
Clarias batrachus | ADP + phosphate + gamma-glutamyl hydroxamate | - |
? | |
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