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Literature summary for 6.2.1.4 extracted from

  • Fleige, T.; Pfaff, N.; Gross, U.; Bohne, W.
    Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii (2008), Int. J. Parasitol., 38, 1121-1132.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene scsA, DNA and amino acid sequence determination and analysis, quantitative expression analysis in in tachyzoites and in vitro bradyzoites, overview Toxoplasma gondii

Protein Variants

Protein Variants Comment Organism
additional information construction of a conditional knock-out mutant for the succinyl-CoA synthetase ScsA, depletion mutant displays a 30% reduction in growth rate, which can be restored by supplementation with 0.002 mM succinate in the tissue culture medium, the mitochondrial membrane potential in these parasites is unaltered, lack of a more severe phenotype, overview Toxoplasma gondii

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Toxoplasma gondii 16020
-
mitochondrion
-
Toxoplasma gondii 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + succinate + CoA Toxoplasma gondii
-
GDP + phosphate + succinyl-CoA
-
r

Organism

Organism UniProt Comment Textmining
Toxoplasma gondii Q1KSE5 gene scsA
-

Source Tissue

Source Tissue Comment Organism Textmining
bradyzoite
-
Toxoplasma gondii
-
additional information quantitative expression analysis in in tachyzoites and in vitro bradyzoites, overview Toxoplasma gondii
-
tachyzoite
-
Toxoplasma gondii
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + succinate + CoA
-
Toxoplasma gondii GDP + phosphate + succinyl-CoA
-
r

Synonyms

Synonyms Comment Organism
ScsA
-
Toxoplasma gondii
Succinyl-CoA synthetase
-
Toxoplasma gondii

Cofactor

Cofactor Comment Organism Structure
GTP
-
Toxoplasma gondii