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Literature summary for 6.2.1.3 extracted from
- Acyl-CoA synthetase activity in Plasmodium knowlesi-infected erythrocytes displays peculiar substrate specificities (1988), Biochim. Biophys. Acta, 958, 1-9.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | above 13.3 mM | Plasmodium knowlesi |  |
| diphosphate | low inhibition of oleoyl-CoA synthesis | Plasmodium knowlesi | |
| oleoyl-CoA | inhibition of oleoyl-CoA synthesis | Plasmodium knowlesi | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.011 | - |
palmitate | - |
Plasmodium knowlesi | |
| 0.028 | - |
stearate | - |
Plasmodium knowlesi | |
| 0.03 | - |
oleate | - |
Plasmodium knowlesi | |
| 0.041 | - |
linoleate | - |
Plasmodium knowlesi | |
| 0.048 | - |
CoA | - |
Plasmodium knowlesi | |
| 0.059 | - |
arachidonate | - |
Plasmodium knowlesi | |
| 0.73 | - |
ATP | - |
Plasmodium knowlesi | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Plasmodium knowlesi | |
| Mg2+ | Km: 1.554 | Plasmodium knowlesi | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium knowlesi | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | of Macaca mulatta or Macaca fascicularis infected with Plasmodium knowlesi | Plasmodium knowlesi | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + arachidonate + CoA | - |
Plasmodium knowlesi | AMP + diphosphate + arachidonoyl-CoA | - |
? | |
| ATP + linoleate + CoA | - |
Plasmodium knowlesi | AMP + diphosphate + linoleoyl-CoA | - |
? | |
| ATP + oleate + CoA | - |
Plasmodium knowlesi | AMP + diphosphate + oleoyl-CoA | - |
? | |
| ATP + palmitate + CoA | - |
Plasmodium knowlesi | AMP + diphosphate + palmitoyl-CoA | - |
? | |
| ATP + stearate + CoA | - |
Plasmodium knowlesi | AMP + diphosphate + stearoyl-CoA | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
half-life of palmitoyl-CoA synthetase activity: 18 min, half-life of oleoyl-CoA synthetase activity: 4 min, half-life of arachidonyl-CoA synthetase activity: 49 min | Plasmodium knowlesi |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | - |
Plasmodium knowlesi |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.8 | 6.5: about 50% of maximal activity, 8.8: about 70% of maximal activity | Plasmodium knowlesi |
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