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Literature summary for 6.2.1.1 extracted from

  • Falcon, A.A.; Chen, S.; Wood, M.S.; Aris, J.P.
    Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae (2010), Mol. Cell. Biochem., 333, 99-108.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isoform ACS2 is localized primarily to the nucleus, with a minor amount in the cytosol Saccharomyces cerevisiae 5829
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nucleus isoform ACS2 is localized primarily to the nucleus, with a minor amount in the cytosol Saccharomyces cerevisiae 5634
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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General Information

General Information Comment Organism
physiological function an acs2 deletion strain has a reduced replicative life span compared to wild-type and isoform acs1 deletion strains. Replicatively aged acs2 deletion cells contain elevated levels of extrachromosomal rDNA circles, and silencing at the rDNA locus is impaired in an acs2 deletion strain Saccharomyces cerevisiae