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Literature summary for 6.1.1.17 extracted from

  • Bernier, S.; Dubois, D.Y.; Habegger-Polomat, C.; Gagnon, L.P.; Lapointe, J.; Chenevert, R.
    Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase (2005), J. Enzyme Inhib. Med. Chem., 20, 61-67.
    View publication on PubMed
Search for more literature for 6.1.1.17

Inhibitors

Inhibitors Comment Organism Structure
5'-O-(N'-(L-pyroglutamyl)-sulfamoyl)adenosine weak Escherichia coli
5'-O-(N-(L-glutamyl)-sulfamoyl)adenosine potent competitive with respect to glutamic acid Escherichia coli
5'-O-(N-(L-glutamyl)-sulfamoyl)adenosine potent competitive with respect to glutamic acid Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
 Glu
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + tRNAGlu
-
 Mus musculus AMP + diphosphate + L-glutamyl-tRNAGlu
-
 ?
ATP + L-glutamate + tRNAGlu
-
 Escherichia coli AMP + diphosphate + L-glutamyl-tRNAGlu
-
 ?

Synonyms

Synonyms Comment Organism
Glutamyl-tRNA synthetase
-
 Mus musculus
Glutamyl-tRNA synthetase
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000028
-
 5'-O-(N-(L-glutamyl)-sulfamoyl)adenosine
-
 Escherichia coli
0.00007
-
 5'-O-(N-(L-glutamyl)-sulfamoyl)adenosine
-
 Mus musculus
0.015
-
 5'-O-(N'-(L-pyroglutamyl)-sulfamoyl)adenosine
-
 Escherichia coli