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Literature summary for 6.1.1.1 extracted from
- A brief perspective of the determination of crystal structures of site-directed mutants of tyrosyl-tRNA synthetase (2011), Protein Eng., 24, 229-231.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| T51 mutants of tyrosyl-tRNA synthetase | Geobacillus stearothermophilus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| T51A | the mutant demonstrates an increase in activity | Geobacillus stearothermophilus |
| T51G | the mutant demonstrates an increase in activity | Geobacillus stearothermophilus |
| T51P | the mutant demonstrates a 25fold increase in activity compared to the wild type enzyme | Geobacillus stearothermophilus |
| T51S | the mutant demonstrates an increase in activity | Geobacillus stearothermophilus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-tyrosine + tRNATyr | Geobacillus stearothermophilus | - |
AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Geobacillus stearothermophilus | P00952 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Geobacillus stearothermophilus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-tyrosine + tRNATyr | - |
Geobacillus stearothermophilus | AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Tyrosyl-tRNA synthetase | - |
Geobacillus stearothermophilus |
| YTS | - |
Geobacillus stearothermophilus |
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