Protein Variants | Comment | Organism |
---|---|---|
H232S | site-directed mutagenesis, mutant energy profile compared to the wild-type enzyme | Homo sapiens |
H232T | site-directed mutagenesis, mutant energy profile compared to the wild-type enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3S)-2,3-epoxy-2,3-dihydrosqualene | Homo sapiens | - |
lanosterol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol | catalytic mechanism involving His232 via intermediates parkeol and protosta-12,24-dien-3-beta-ol, quantum mechanics/molecular mechanics, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3S)-2,3-epoxy-2,3-dihydrosqualene | - |
Homo sapiens | lanosterol | - |
? | |
(3S)-2,3-epoxy-2,3-dihydrosqualene | reaction of wild-type enzyme, via intermediates parkeol and protosta-12,24-dien-3-beta-ol | Homo sapiens | lanosterol | - |
? | |
(3S)-2,3-epoxy-2,3-dihydrosqualene | reaction of mutant H232S | Homo sapiens | parkeol | - |
? | |
(3S)-2,3-epoxy-2,3-dihydrosqualene | reaction of mutant H232T | Homo sapiens | protosta-12,24-dien-3-beta-ol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
OSC | - |
Homo sapiens |
Oxidosqualene-lanosterol cyclase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | oxidosqualene-lanosterol cyclase is a key enzyme in the biosynthesis of cholesterol | Homo sapiens |
additional information | H232 mutant energy profiles compared to the wild-type enzyme, overview | Homo sapiens |