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Literature summary for 5.4.99.7 extracted from

  • Seiki, S.; Frishman, W.H.
    Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia (2009), Cardiol. Rev., 17, 70-76.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
U18666A produce cataract formation Metazoa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-squalene-2,3-epoxide Metazoa
-
Lanosterol
-
?

Organism

Organism UniProt Comment Textmining
Metazoa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-squalene-2,3-epoxide
-
Metazoa Lanosterol
-
?

Synonyms

Synonyms Comment Organism
2,3 oxidosqualene:lanosterol cyclase
-
Metazoa
Oxidosqualene cyclase
-
Metazoa

General Information

General Information Comment Organism
metabolism part of cholesterol synthesis pathway Metazoa