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Literature summary for 5.4.99.7 extracted from

  • Wu, T.K.; Yu, M.T.; Liu, Y.T.; Chang, C.H.; Wang, H.J.; Diau, E.W.
    Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions (2006), Org. Lett., 8, 1319-1322.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
W232A products are 18.1% protosta-12,24-dien-3beta-ol, 47.1% lanosterol, 34.8% parkeol Saccharomyces cerevisiae
W232C products are 18% protosta-12,24-dien-3beta-ol, 31.8% lanosterol, 50.2% parkeol Saccharomyces cerevisiae
W232D products are 7.9% protosta-12,24-dien-3beta-ol, 84.8% lanosterol, 7.3% parkeol Saccharomyces cerevisiae
W232E products are 14% protosta-12,24-dien-3beta-ol, 49.2% lanosterol, 36.8% parkeol Saccharomyces cerevisiae
W232F products are 8.4% protosta-12,24-dien-3beta-ol, 74.4% lanosterol, 17,2% parkeol Saccharomyces cerevisiae
W232G products are 8.4% protosta-12,24-dien-3beta-ol, 74.4% lanosterol, 17.2% parkeol Saccharomyces cerevisiae
W232H products are 27.8% protosta-12,24-dien-3beta-ol, 35% lanosterol, 37.2% parkeol Saccharomyces cerevisiae
W232I products are 23.5% protosta-12,24-dien-3beta-ol, 33% lanosterol, 43.5% parkeol Saccharomyces cerevisiae
W232K no catalytic activity Saccharomyces cerevisiae
W232L products are 14.5% protosta-12,24-dien-3beta-ol, 27.8% lanosterol, 57.7% parkeol Saccharomyces cerevisiae
W232M products are 10.9% protosta-12,24-dien-3beta-ol, 40.6% lanosterol, 48.5% parkeol Saccharomyces cerevisiae
W232N products are 10.7% protosta-12,24-dien-3beta-ol, 59.5% lanosterol, 29.8% parkeol Saccharomyces cerevisiae
W232P products are 4.4% protosta-12,24-dien-3beta-ol, 82.9% lanosterol, 12.7% parkeol Saccharomyces cerevisiae
W232Q products are 24.6% protosta-12,24-dien-3beta-ol, 32.1% lanosterol, 43.3% parkeol Saccharomyces cerevisiae
W232R no catalytic activity Saccharomyces cerevisiae
W232S products are 10.7% protosta-12,24-dien-3beta-ol, 59% lanosterol, 30.3% parkeol Saccharomyces cerevisiae
W232T products are 14.3% protosta-12,24-dien-3beta-ol, 61.7% lanosterol, 24% parkeol Saccharomyces cerevisiae
W232V products are 19.3% protosta-12,24-dien-3beta-ol, 34% lanosterol, 46.7% parkeol Saccharomyces cerevisiae
W232Y products are 4.2% protosta-12,24-dien-3beta-ol, 94.2% lanosterol, 1.6% parkeol Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol W232 plays a catalytic role influencing the rearrangement process and determination of deprotonation position but does not interact in the cyclization process Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2,3-epoxysqualene
-
 Saccharomyces cerevisiae lanosterol lanosterol is the only product in wild-type ?