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Literature summary for 5.4.99.7 extracted from

  • Oliaro-Bosso, S.; Viola, F.; Matsuda, S.; Cravotto, G.; Tagliapietra, S.; Balliano, G.
    Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi, and Pneumocystis carinii (2004), Lipids, 39, 1007-1012.
    View publication on PubMed
Search for more literature for 5.4.99.7

Application

Application Comment Organism
drug development results identify a particularly promising new family of OSC inhibitors, for the development of novel antiparasitic agents Saccharomyces cerevisiae
drug development results identify a particularly promising new family of OSC inhibitors, for the development of novel antiparasitic agents Trypanosoma cruzi
drug development results identify a particularly promising new family of OSC inhibitors, for the development of novel antiparasitic agents Pneumocystis carinii

Cloned(Commentary)

Cloned (Comment) Organism
-
 Saccharomyces cerevisiae
expression in Saccharomyces cerevisiae Trypanosoma cruzi
expression in Saccharomyces cerevisiae Pneumocystis carinii

Inhibitors

Inhibitors Comment Organism Structure
3-beta-(beta-dimethylaminoethoxy)-androst-5en-17one DMAE-DHA Pneumocystis carinii
3-beta-(beta-dimethylaminoethoxy)-androst-5en-17one DMAE-DHA Saccharomyces cerevisiae
3-beta-(beta-dimethylaminoethoxy)-androst-5en-17one DMAE-DHA Trypanosoma cruzi
7-(4-allylmethylamino-but-2-ynyloxy)chromen-2-one
-
 Pneumocystis carinii
7-(4-allylmethylamino-but-2-ynyloxy)chromen-2-one
-
 Saccharomyces cerevisiae
7-(4-allylmethylamino-but-2-ynyloxy)chromen-2-one
-
 Trypanosoma cruzi
7-(morpholinyl-N-hexyloxy)chromen-2-one
-
 Pneumocystis carinii
7-(morpholinyl-N-hexyloxy)chromen-2-one
-
 Saccharomyces cerevisiae
7-(morpholinyl-N-hexyloxy)chromen-2-one
-
 Trypanosoma cruzi
7-(morpholinyl-N-octanyloxy)chromen-2-one
-
 Pneumocystis carinii
7-(morpholinyl-N-octanyloxy)chromen-2-one
-
 Saccharomyces cerevisiae
7-(morpholinyl-N-octanyloxy)chromen-2-one
-
 Trypanosoma cruzi
7-(piperidinyl-N-hexyloxy)chromen-2-one
-
 Pneumocystis carinii
7-(piperidinyl-N-hexyloxy)chromen-2-one
-
 Saccharomyces cerevisiae
7-(piperidinyl-N-hexyloxy)chromen-2-one
-
 Trypanosoma cruzi
7-[10-(allylmethylamino)-decyloxy]chromen-2-one
-
 Pneumocystis carinii
7-[10-(allylmethylamino)-decyloxy]chromen-2-one
-
 Saccharomyces cerevisiae
7-[10-(allylmethylamino)-decyloxy]chromen-2-one
-
 Trypanosoma cruzi
7-[4'-(N-diethylamino)-but-2-ynyloxy]chromen-2-one
-
 Pneumocystis carinii
7-[4'-(N-diethylamino)-but-2-ynyloxy]chromen-2-one
-
 Saccharomyces cerevisiae
7-[4'-(N-diethylamino)-but-2-ynyloxy]chromen-2-one
-
 Trypanosoma cruzi
7-[4'-(N-pyrrolidyn)-but-2-ynyloxy]chromen-2-one
-
 Pneumocystis carinii
7-[4'-(N-pyrrolidyn)-but-2-ynyloxy]chromen-2-one
-
 Saccharomyces cerevisiae
7-[4'-(N-pyrrolidyn)-but-2-ynyloxy]chromen-2-one
-
 Trypanosoma cruzi
7-[6-(allylmethylamino)-hexyloxy]-chromen-2-one
-
 Pneumocystis carinii
7-[6-(allylmethylamino)-hexyloxy]-chromen-2-one
-
 Saccharomyces cerevisiae
7-[6-(allylmethylamino)-hexyloxy]-chromen-2-one
-
 Trypanosoma cruzi
7-[8'(dimethylamino-N-octyloxy)]chromen-2-one
-
 Pneumocystis carinii
7-[8'(dimethylamino-N-octyloxy)]chromen-2-one
-
 Saccharomyces cerevisiae
7-[8'(dimethylamino-N-octyloxy)]chromen-2-one
-
 Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
spheroplast
-
 Saccharomyces cerevisiae
-
-
spheroplast
-
 Trypanosoma cruzi
-
-
spheroplast
-
 Pneumocystis carinii
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-oxidosqualene Saccharomyces cerevisiae
-
 lanosterol
-
 ?
2,3-oxidosqualene Trypanosoma cruzi
-
 lanosterol
-
 ?
2,3-oxidosqualene Pneumocystis carinii
-
 lanosterol
-
 ?

Organism

Organism UniProt Comment Textmining
Pneumocystis carinii
-
-
-
Saccharomyces cerevisiae
-
-
-
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-oxidosqualene
-
 Saccharomyces cerevisiae lanosterol
-
 ?
2,3-oxidosqualene
-
 Trypanosoma cruzi lanosterol
-
 ?
2,3-oxidosqualene
-
 Pneumocystis carinii lanosterol
-
 ?

Synonyms

Synonyms Comment Organism
OSC
-
 Saccharomyces cerevisiae
OSC
-
 Trypanosoma cruzi
OSC
-
 Pneumocystis carinii
Oxidosqualene cyclase
-
 Saccharomyces cerevisiae
Oxidosqualene cyclase
-
 Trypanosoma cruzi
Oxidosqualene cyclase
-
 Pneumocystis carinii

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 7-(4-allylmethylamino-but-2-ynyloxy)chromen-2-one above 0.1 mM Trypanosoma cruzi
additional information
-
 7-(piperidinyl-N-hexyloxy)chromen-2-one above 0.1 mM Trypanosoma cruzi
0.00015
-
 7-[6-(allylmethylamino)-hexyloxy]-chromen-2-one
-
 Pneumocystis carinii
0.00018
-
 7-[10-(allylmethylamino)-decyloxy]chromen-2-one
-
 Pneumocystis carinii
0.00052
-
 7-[4'-(N-pyrrolidyn)-but-2-ynyloxy]chromen-2-one
-
 Pneumocystis carinii
0.00104
-
 7-[8'(dimethylamino-N-octyloxy)]chromen-2-one
-
 Pneumocystis carinii
0.00104
-
 7-[6-(allylmethylamino)-hexyloxy]-chromen-2-one
-
 Saccharomyces cerevisiae
0.00112
-
 7-(4-allylmethylamino-but-2-ynyloxy)chromen-2-one
-
 Pneumocystis carinii
0.00185
-
 7-[4'-(N-diethylamino)-but-2-ynyloxy]chromen-2-one
-
 Pneumocystis carinii
0.00248
-
 7-(piperidinyl-N-hexyloxy)chromen-2-one
-
 Pneumocystis carinii
0.00321
-
 7-[10-(allylmethylamino)-decyloxy]chromen-2-one
-
 Saccharomyces cerevisiae
0.00342
-
 7-(4-allylmethylamino-but-2-ynyloxy)chromen-2-one
-
 Saccharomyces cerevisiae
0.00406
-
 7-[6-(allylmethylamino)-hexyloxy]-chromen-2-one
-
 Trypanosoma cruzi
0.00414
-
 7-[10-(allylmethylamino)-decyloxy]chromen-2-one
-
 Trypanosoma cruzi
0.00535
-
 7-(morpholinyl-N-octanyloxy)chromen-2-one
-
 Pneumocystis carinii
0.00603
-
 7-[8'(dimethylamino-N-octyloxy)]chromen-2-one
-
 Saccharomyces cerevisiae
0.01028
-
 7-[4'-(N-pyrrolidyn)-but-2-ynyloxy]chromen-2-one
-
 Saccharomyces cerevisiae
0.02035
-
 7-[4'-(N-diethylamino)-but-2-ynyloxy]chromen-2-one
-
 Saccharomyces cerevisiae
0.02543
-
 7-[8'(dimethylamino-N-octyloxy)]chromen-2-one
-
 Trypanosoma cruzi
0.03067
-
 7-(morpholinyl-N-octanyloxy)chromen-2-one
-
 Saccharomyces cerevisiae
0.03154
-
 7-(piperidinyl-N-hexyloxy)chromen-2-one
-
 Saccharomyces cerevisiae
0.07266
-
 7-[4'-(N-diethylamino)-but-2-ynyloxy]chromen-2-one
-
 Trypanosoma cruzi
0.07876
-
 7-(morpholinyl-N-hexyloxy)chromen-2-one
-
 Pneumocystis carinii
0.09583
-
 7-(morpholinyl-N-hexyloxy)chromen-2-one
-
 Trypanosoma cruzi
0.1024
-
 7-(morpholinyl-N-octanyloxy)chromen-2-one
-
 Trypanosoma cruzi
0.1028
-
 7-(morpholinyl-N-hexyloxy)chromen-2-one
-
 Saccharomyces cerevisiae
0.1063
-
 7-[4'-(N-pyrrolidyn)-but-2-ynyloxy]chromen-2-one
-
 Trypanosoma cruzi