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Literature summary for 5.4.99.7 extracted from

  • Tanaka, R.; Sakano, Y.; Nagatsu, A.; Shibuya, M.; Ebizuka, Y.; Goda, Y.
    Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase (2005), Bioorg. Med. Chem. Lett., 15, 159-162.
    View publication on PubMed

Application

Application Comment Organism
nutrition since lanosterol synthase is located in the middle stage of the biosynthetic pathway of cholesterol in mammals, it may be important to know the acyl composition of digalactosyl diacylglycerol in vegetables for evaluating the efficacy of them against hypercholesterolemia Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,2-dilinoleoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 26% inhibition at 0.5 microM, no inhibition at 0.25 microM Homo sapiens
1,2-dimyristoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 72% inhibition at 0.5 microM, 51% at 0.25 microM Homo sapiens
1,2-dioleoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 57% inhibition at 0.5 microM, 42% at 0.25 microM Homo sapiens
1,2-dipalmitoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 24% inhibition at 0.5 microM, 4% at 0.25 microM Homo sapiens
1-linolenoyl-2-palmitoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 26% inhibition at 0.5 microM, 5% inhibition at 0.25 microM Homo sapiens
1-linoleoyl-2-linolenoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 45% inhibition at 0.5 microM, 18% at 0.25 microM Homo sapiens
1-linoleoyl-2-myristoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 38% inhibition at 0.5 microM, 22% at 0.25 microM Homo sapiens
1-linoleoyl-2-oleoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 31% inhibition at 0.5 microM, 8% at 0.25 microM Homo sapiens
1-linoleoyl-2-palmitoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 27% inhibition at 0.5 microM, 3% at 0.25 microM Homo sapiens
1-myristoyl-2-palmitoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 45% inhibition at 0.5 microM, 35% at 0.25 microM Homo sapiens
1-oleoyl-2-linolenoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 29% inhibition at 0.5 microM, 7% at 0.25 microM Homo sapiens
1-oleoyl-2-linoleoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 40% inhibition at 0.5 microM, 9% at 0.25 microM Homo sapiens
1-oleoyl-2-palmitoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 46% inhibition at 0.5 microM, 24% at 0.25 microM Homo sapiens
1-palmitoyl-2-linoleoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 20% inhibition at 0.5 microM, no inhibition at 0.25 microM Homo sapiens
1-palmitoyl-2-oleoyl-3-(alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl)-sn-glycerol 21% inhibition at 0.5 microM, 4% at 0.25 microM Homo sapiens
additional information 3-alpha-D-galactopyranosyl-1,6-beta-D-galactopyranosyl-sn-glycerol has no inhibitory effect Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
oxidosqualene
-
Homo sapiens lanosterol
-
?

Synonyms

Synonyms Comment Organism
lanosterol synthase
-
Homo sapiens