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Literature summary for 5.4.99.7 extracted from

  • Cattel, L.; Ceruti, M.
    Inhibitors of 2,3-oxidosqualene cyclase as tools for studying the mechanism and function of the enzyme (1998), Crit. Rev. Biochem. Mol. Biol., 33, 353-373.
    View publication on PubMed
Search for more literature for 5.4.99.7

Inhibitors

Inhibitors Comment Organism Structure
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide IC50: 0.003 mM, at a protein concentration of 3 mg/ml Candida albicans
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide IC50: 0.0048 mM, at a protein concentration of 5 mg/ml Rattus norvegicus
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide IC50: 0.005 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide IC50: 0.005 mM, at a protein concentration of 1 mg/ml Sus scrofa
(6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide IC50: above 0.1 mM, at a protein concentration of 3 mg/ml Candida albicans
(6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide IC50: above 0.02 mM, at a protein concentration of 5 mg/ml Rattus norvegicus
(6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide IC50: above 0.1 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae
19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide IC50: 0.022 mM, protein concentration of 3 mg/ml Candida albicans
19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide IC50: 0.0075 mM, protein concentration of 5 mg/ml Rattus norvegicus
19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide IC50: 0.035 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae
19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide IC50: 0.0015 mM Sus scrofa
2-Aza-2,3-dihydrosqualene 0.01 mM, 70% inhibition; IC50: 6.5 mM Candida albicans
2-Aza-2,3-dihydrosqualene 0.01 mM, 70% inhibition; IC50: 7.5 mM Rattus norvegicus
2-Aza-2,3-dihydrosqualene 0.01 mM, 70% inhibition; IC50: 10 mM Saccharomyces cerevisiae
2-Aza-2,3-dihydrosqualene IC50: 2.3 mM, pig microsomes. IC50: 0.15 mM, solubilized enzyme Sus scrofa
2-Aza-2,3-dihydrosqualene N-oxide IC50: 3.7 mM Rattus norvegicus
2-Aza-2,3-dihydrosqualene N-oxide IC50: 16 mM Saccharomyces cerevisiae
2-Aza-2,3-dihydrosqualene N-oxide IC50: 7 mM, pig microsomes. IC50: 3.3 mM, solubilized enzyme Sus scrofa
22,23-epoxy-2-aza-2,3-dihydrosqualene-N-oxide 0.01 mM, 14% inhibition Rattus norvegicus
3-carboxy-4-nitrophenyldithio-1,1',2-tris-nor-squalene
-
 Saccharomyces cerevisiae
3-[Methyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-amino]-propan-1-ol 0.01 mM, 2% inhibition Rattus norvegicus
azasqualene alcohol 0.01 mM, 13% inhibition Rattus norvegicus
azasqualene alcohol N-oxide IC50: 0.055 mM, at a protein concentration of 3 mg/ml Candida albicans
azasqualene alcohol N-oxide IC50: 0.055 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae
diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide IC50: 1.5 mM Rattus norvegicus
diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide IC50: 14 mM Saccharomyces cerevisiae
Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium IC50: 3.2 mM Rattus norvegicus
Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium IC50: 12.5 mM Saccharomyces cerevisiae
Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium IC50: 13.3 mM Candida albicans
Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium IC50: 5.1 mM Rattus norvegicus
[19-(3,3-Dimethyl-oxiranyl)-4,8,13,17-tetramethyl-nonadeca-4,8,12,16-tetraenyl]-dimethyl-amine 0.01 mM, 8% inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Sus scrofa
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
-
 Rattus norvegicus
78000
-
-
 Saccharomyces cerevisiae
78000
-
-
 Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Canis lupus familiaris
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus
-
 Sus scrofa
-
 Saccharomyces cerevisiae
-
 Canis lupus familiaris
-
 Candida albicans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0015
-
 IC50: 0.0015 mM Sus scrofa 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
0.003
-
 IC50: 0.003 mM, at a protein concentration of 3 mg/ml Candida albicans (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
0.0048
-
 IC50: 0.0048 mM, at a protein concentration of 5 mg/ml Rattus norvegicus (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
0.005
-
 IC50: 0.005 mM, at a protein concentration of 1 mg/ml Sus scrofa (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
0.005
-
 IC50: 0.005 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae (6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide
0.0075
-
 IC50: 0.0075 mM, protein concentration of 5 mg/ml Rattus norvegicus 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
0.02
-
 IC50: above 0.02 mM, at a protein concentration of 5 mg/ml Rattus norvegicus (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
0.022
-
 IC50: 0.022 mM, protein concentration of 3 mg/ml Candida albicans 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
0.035
-
 IC50: 0.035 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae 19-aza-18,19,22,23-tetrahydrosqualene-2,3-epoxide
0.055
-
 IC50: 0.055 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae azasqualene alcohol N-oxide
0.055
-
 IC50: 0.055 mM, at a protein concentration of 3 mg/ml Candida albicans azasqualene alcohol N-oxide
0.1
-
 IC50: above 0.1 mM, at a protein concentration of 2 mg/ml Saccharomyces cerevisiae (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
0.1
-
 IC50: above 0.1 mM, at a protein concentration of 3 mg/ml Candida albicans (6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide
0.15
-
 IC50: 2.3 mM, pig microsomes. IC50: 0.15 mM, solubilized enzyme Sus scrofa 2-Aza-2,3-dihydrosqualene
1.5
-
 IC50: 1.5 mM Rattus norvegicus diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide
3.2
-
 IC50: 3.2 mM Rattus norvegicus Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
3.3
-
 IC50: 7 mM, pig microsomes. IC50: 3.3 mM, solubilized enzyme Sus scrofa 2-Aza-2,3-dihydrosqualene N-oxide
3.7
-
 IC50: 3.7 mM Rattus norvegicus 2-Aza-2,3-dihydrosqualene N-oxide
5.1
-
 IC50: 5.1 mM Rattus norvegicus Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
6.5
-
 IC50: 6.5 mM Candida albicans 2-Aza-2,3-dihydrosqualene
7.5
-
 IC50: 7.5 mM Rattus norvegicus 2-Aza-2,3-dihydrosqualene
10
-
 IC50: 10 mM Saccharomyces cerevisiae 2-Aza-2,3-dihydrosqualene
12.5
-
 IC50: 12.5 mM Saccharomyces cerevisiae Diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
13.3
-
 IC50: 13.3 mM Candida albicans Trimethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-ammonium
14
-
 IC50: 14 mM Saccharomyces cerevisiae diethyl-(4,8,13,17,21-pentamethyl-docosa-4,8,12,16,20-pentaenyl)-aminoxide
16
-
 IC50: 16 mM Saccharomyces cerevisiae 2-Aza-2,3-dihydrosqualene N-oxide