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Literature summary for 5.4.99.7 extracted from
- Some properties of the microsomal 2,3-oxidosqualene sterol cyclase (1969), Proc. Natl. Acad. Sci. USA, 63, 110-117.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| deoxycholate | the effective concentration range for enzyme activation is extremely narrow, around 0.1%. The enzyme activity may depend not only on the final concentration of sodium deoxycholate but also on its ratio to protein | Sus scrofa |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | in solutions of low ionic strength the enzyme polymerizes to an inactive form | Sus scrofa |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.025 | - |
2,3-epoxysqualene | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Sus scrofa | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 90000 | - |
gel filtration | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
hog | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, stable for at least several months | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-squalene-2,3-epoxide | - |
Sus scrofa | Lanosterol | - |
? | |
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