Any feedback?
Literature summary for 5.4.99.17 extracted from
- Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation (2013), Curr. Opin. Chem. Biol., 17, 293-300.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| squalene | Alicyclobacillus acidocaldarius | - |
hop-22(29)-ene | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Alicyclobacillus acidocaldarius | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| squalene = hop-22(29)-ene | catalytic mechanism, overview | Alicyclobacillus acidocaldarius |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme shows substrate diversity for polycyclization reactions, since squalene-hopene cyclases specifically address and protonate terminal double bonds of linear terpenoids, molecules with functional groups like carboxylic acids or amides can be used as substrates, overview. It is active with squalene, a C-35 squalene analogue substrate, farnesol, and geranyl geraniol, but not with geraniol, products overview | Alicyclobacillus acidocaldarius | ? | - |
? | |
| squalene | - |
Alicyclobacillus acidocaldarius | hop-22(29)-ene | - |
? | |
| squalene | - |
Alicyclobacillus acidocaldarius | hop-22(29)-ene | hopanol is also formed | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SHC | - |
Alicyclobacillus acidocaldarius |
| squalene hopene cyclase | - |
Alicyclobacillus acidocaldarius |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | squalene hopene cyclases are class II triterpene synthases that use a proton-initiated cationic polycyclization cascade to form carbopolycyclic products. The class II mechanism involves the Broensted acid sequence motif DxDD, catalytic mechanism compared to terpene cyclases, overview | Alicyclobacillus acidocaldarius |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
