Literature summary for 5.4.2.6 extracted from

Tremblay, L.W.; Zhang, G.; Dai, J.; Dunaway-Mariano, D.; Allen, K.N.
Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase (2005), J. Am. Chem. Soc., 127, 5298-5299.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
both in complex with inhibitor alpha-D-galactose 1-phosphate or substrate beta-D-glucose 1-phosphate	Lactococcus lactis

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-D-galactose 1-phosphate	competitive	Lactococcus lactis

Organism

Organism	UniProt	Comment	Textmining
Lactococcus lactis	P71447	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
beta-D-Glucose 1-phosphate = beta-D-glucose 6-phosphate	mechanism is a nucleophilic substitution via an associative pathway, enzyme stablizes the phosphorane intermediate along that pathway	Lactococcus lactis	a

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.03	-	alpha-D-galactose 1-phosphate	-	Lactococcus lactis

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Release 2023.1 (January 2023)