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Literature summary for 5.3.99.3 extracted from

  • Nakatani, Y.; Hokonohara, Y.; Tajima, Y.; Kudo, I.; Hara, S.
    Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH (2011), Prostaglandins Other Lipid Mediat., 94, 112-117.
    View publication on PubMed
Search for more literature for 5.3.99.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Mus musculus
-
 Prostaglandin E2
-
 ?
Prostaglandin H2 Rattus norvegicus
-
 Prostaglandin E2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3Y1 cell
-
 Rattus norvegicus
-
embryonic fibroblast
-
 Mus musculus
-
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Mus musculus Prostaglandin E2
-
 ?
Prostaglandin H2
-
 Rattus norvegicus Prostaglandin E2
-
 ?

Synonyms

Synonyms Comment Organism
CPGES
-
 Mus musculus
CPGES
-
 Rattus norvegicus
p23
-
 Mus musculus
p23
-
 Rattus norvegicus
Prostaglandin E synthase
-
 Mus musculus
Prostaglandin E synthase
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction embryonic fibroblasts deficient in cPGES/p23 decrease the expression of the prostaglandin E2 degrading enzyme, 15-hydroxyprostaglandin dehydrogenase, which catalyzes the inactivating conversion of the PGE2 15-OH to a 15-keto group Mus musculus
malfunction fibroblasts deficient in cPGES/p23 decrease the expression of the prostaglandin E2 degrading enzyme, 15-hydroxyprostaglandin dehydrogenase, which catalyzes the inactivating conversion of the PGE2 15-OH to a 15-keto group Rattus norvegicus
metabolism the prostaglandin E2-inactivating pathway is controlled by cPGES/p23 Mus musculus
metabolism the prostaglandin E2-inactivating pathway is controlled by cPGES/p23 Rattus norvegicus