Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac endothelial cell | - |
Mus musculus | - |
cardiac endothelium | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Mus musculus | Prostaglandin E2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E synthase-1 | - |
Mus musculus |
mPGES-1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | inhibition of NADPH-oxidase negatively modulates mPGES-1 expression induced by tobacco smoke/interleukin-1beta. The activation of mPGES-1 is negatively regulated by prostaglandin I2 | down |
Mus musculus | tobacco smoke (EC50 about 5 puffs/l) interacting with IL-1beta (0.002 mg/l) upregulates PGE2 production and mPGES-1 expression, reaching a plateau at 4-6 h | up |