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Literature summary for 5.3.99.3 extracted from

  • Sveinbjoernsson, B.; Schumacher, M.C.; Hamberg, M.; Samuelsson, B.; Jakobsson, P.J.; Kogner, P.; Radmark, O.
    Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells (2009), Proc. Natl. Acad. Sci. USA, 106, 18757-18762.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine MPGES-1 is an alternative therapeutic target in cancer cells expressing this enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Homo sapiens
-
Prostaglandin E2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
DU-145 cell
-
Homo sapiens
-
additional information MPGES-1 is not detected in LNCaP cells Homo sapiens
-
PC-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
Homo sapiens Prostaglandin E2
-
?

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase 1
-
Homo sapiens
mPGES-1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens interleukin-1beta does not change expression of MPGES-1 in the prostate cancer cell lines additional information