Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
indomethacin | - |
Homo sapiens | |
indomethacin | - |
Rattus norvegicus | |
MK-886 | - |
Homo sapiens | |
MK-886 | - |
Rattus norvegicus | |
PF-9184 | potent, competitive and reversible mPGES-1 inhibitor, i.e. N-(3',4'-dichlorobiphenyl-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide | Homo sapiens | |
PF-9184 | poor mPGES-1 inhibitor, i.e. N-(3',4'-dichlorobiphenyl-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide | Rattus norvegicus | |
SC-236 | - |
Homo sapiens | |
SC-236 | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? | |
Prostaglandin H2 | - |
Rattus norvegicus | Prostaglandin E2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E synthase-1 | - |
Homo sapiens |
microsomal prostaglandin E synthase-1 | - |
Rattus norvegicus |
mPGES-1 | - |
Homo sapiens |
mPGES-1 | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000165 | - |
recombinant enzyme, in 100 mM K3PO4 buffer at pH 6.2 | Homo sapiens | PF-9184 | |
0.00108 | - |
in 100 mM K3PO4 buffer at pH 6.2 | Rattus norvegicus | PF-9184 |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is responsible for prostaglandin E2 synthesis in inflammation-associated pathologies | Homo sapiens |
physiological function | the enzyme is responsible for prostaglandin E2 synthesis in inflammation-associated pathologies | Rattus norvegicus |